It's official! We now have an R client for querying MyVariant.info annotation services. The package, myvariant, can be installed from Bioconductor (>v3.2) by running the following commands from your R console:

source("http://bioconductor.org/biocLite.R")
biocLite("myvariant")

Bioconductor provides several packages for seamless interaction with Next Generation Sequencing data. Now, comprehensive variant annotation can be added to a workflow using myvariant in R, without the need to download any local databases. Follow this link for a complete preview of the package, including an example use case demonstration.

Additional examples can be found from the vignette and reference manual at the myvariant package page. As always, feel free to reach us at help@myvariant.info or
@myvariantinfo if you have any questions or feedback.