Just a quick highlight of our recent update on all pathway data in MyGene.info API. Thanks to the excellent pathway/interaction database from ConsensusPathDB, we updated all 10 pathway sub-fields (listed below) for three species (human, mouse and yeast). The underlying data were updated up to Jan 2017 (ConsensusPathDB release 32). Here are some more details.

Pathway data from MyGene.info

With MyGene.info API, users can access 10 pathway related fields, nested under "pathway" field:

field in MyGene.info	# of genes with the pathway field
	previous version	current version
pathway.biocarta	1386	1414
pathway.humancyc	1175	1191
pathway.kegg	16281	16495
pathway.mousecyc	1225	1225
pathway.pharmgkb	878	877
pathway.pid	2618	2656
pathway.reactome	14797	17170
pathway.smpdb	1047	1064
pathway.wikipathways	11095	11955
pathway.yeastcyc	641	641

As you can tell, Reactome and WikiPathways are the two still actively updated, while the rest of pathway DBs are pretty much unchanged. Minor changes are mostly due to the changes of underlying gene annotations. These DBs are either no longer updated or closed up due to the license restrictions.

Query examples with pathway data

• Retrieve specific pathway field(s) for a given gene

  curl 'http://mygene.info/v3/gene/1017?fields=pathway'
  curl 'http://mygene.info/v3/gene/1017?fields=pathway.reactome'
  curl 'http://mygene.info/v3/gene/1017?fields=pathway.reactome,pathway.wikipathways'

Or using our mygene Python client:

   import mygene
   mg = mygene.MyGeneinfo()
   mg.getgene(1017, fields='pathway)
   mg.getgene(1017, fields='pathway.reactome')
   mg.getgene(1017, fields='pathway.reactome,pathway.wikipathways')

Batch query is possible using POST：

curl -X POST \
  http://mygene.info/v3/gene \
  -H 'content-type: application/x-www-form-urlencoded' \
  -d 'ids=1017,1018&fields=pathway.reactome'

or

mg.getgenes([1017,1018], fields='pathway.reactome')

• Query pathways for matching genes

# Return genes from Reactome pathway "R-HSA-3700989" (Transcriptional Regulation by TP53):
curl 'http://mygene.info/v3/query?q=pathway.reactome.id:R-HSA-3700989'
# or in Python:
mg.query('pathway.reactome.id:R-HSA-3700989')

# By default, top 10 genes are returned, but you can use size and from parameter to page through all matching genes:
curl 'http://mygene.info/v3/query?q=pathway.reactome.id:R-HSA-3700989&size=500'
# or in Python:
mg.query('pathway.reactome.id:R-HSA-3700989', size=500)

curl 'http://mygene.info/v3/query?q=pathway.reactome.id:R-HSA-3700989&size=50&from=50'
# or in Python:
mg.query('pathway.reactome.id:R-HSA-3700989', size=50, skip=50)

# Return matching genes from any wikipathways pathways mention "apoptosis":
curl 'http://mygene.info/v3/query?q=pathway.wikipathways.name:apoptosis&fields=pathway.wikipathways,name,symbol'
# or in Python:
mg.query('pathway.wikipathways.name:apoptosis', fields='pathway.wikipathways,name,symbol')

As always, feel free to reach us at help@mygene.info or @mygeneinfo if you have any questions or feedback.